Actinic Keratosis (A Precancerous Condition)

What is actinic keratosis?

Actinic keratosis can be the first step in the development of skin cancer, and, therefore, is considered a precancerous skin condition. The presence of actinic keratoses indicates that sun damage has occurred and that any kind of skin cancer can develop.

How does an actinic keratosis develop?

An actinic keratosis develops slowly and most likely appears on the face, ears, bald scalp, neck, backs of hands and forearms, and lips. It tends to lie flat against the skin of the head and neck, but appear elevated on arms and hands. Often, a person will have more than one actinic keratosis lesion.

The lesions are usually not life threatening, provided they are detected and treated in the early stages. However, if this is not done, they can grow large and invade the surrounding tissues and, on rare occasions, metastasize, or spread, to the internal organs.

The most aggressive form of keratosis, actinic cheilitis, appears on the lips and can evolve into squamous cell carcinoma. When this happens, about 20 percent of these carcinomas metastasize to other parts of the body.

It is estimated that up to 10 percent of active lesions, which are more red in color and more tender than the rest, will take the next step and progress to squamous cell carcinomas.

What causes actinic keratosis?

Sun exposure causes almost all actinic keratoses. Sun damage to the skin accumulates over time, so that even a brief exposure adds to the lifetime total. Certain groups of people are more at risk than others, including the following:

• People who have fair skin, blonde or red hair, and blue, green, or gray eyes are at the greatest risk, but darker-skinned people can develop keratoses if they expose themselves to the sun without protection.

• African-Americans rarely have these lesions.

• Individuals who are immunosuppressed as a result of cancer chemotherapy, acquired immune deficiency syndrome (AIDS), or organ transplantation are also at higher risk.

One in six people will develop an actinic keratosis in the course of a lifetime, according to some estimates. Older people are more likely than younger people to develop actinic keratoses, because cumulative sun exposure increases with age.

Treatment for actinic keratosis:

Specific treatment for actinic keratosis will be determined by your physician based on:

• your age, overall health, and medical history
• extent of the disease
• your tolerance for specific medications, procedures, or therapies
• expectations for the course of the disease
• your opinion or preference

When diagnosed early, treatment for actinic keratosis may include cryotherapy (freezing the lesion), topical chemotherapy (anticancer drugs), or other treatments.

Click here to view the
Online Resources page of this Web.