Erythema Nodosum

What is erythema nodosum?

Erythema nodosum is characterized by tender, red bumps, usually found on the shins. Quite often, erythema nodosum is not a separate disease, but, rather, a sign of some other disease, or of a sensitivity to a drug.

Diseases that can cause erythema nodosum:

• streptococcal infections
• sarcoidosis (inflammation of the lymph nodes and other organs)
• leprosy
• coccidioidomycosis (infection of the upper respiratory tract and lungs)
• histoplasmosis (an infectious pulmonary disease)
• tuberculosis
• psittacosis (a flu-like disease)
• lymphogranuloma venereum (a venereal infection)
• ulcerative colitis

Drugs that can cause erythema nodosum:

• antibiotics containing sulfa
• bromides
• iodides
• oral contraceptives

What are the symptoms of erythema nodosum?

The following are the most common symptoms of erythema nodosum. However, each individual may experience symptoms differently. Symptoms may include:

• raised bruises on the shins
• fever
• joint pain
• enlarged lymph nodes in the chest

Young adults are particularly susceptible to erythema nodosum. The symptoms of erythema nodosum may resemble other skin conditions. Always consult your physician for a diagnosis.

How is erythema nodosum diagnosed?

A biopsy (removal of tissue for examination under a microscope) of a bump can usually confirm the diagnosis. However, the exact cause cannot always be identified. Drug-induced erythema nodosum can usually be diagnosed by careful elimination of the drug causing the reaction.

Treatment for erythema nodosum:

Specific treatment for erythema nodosum will be determined by your physician based on:

• your age, overall health, and medical history
• extent of the condition
• your tolerance for specific medications, procedures, or therapies
• expectations for the course of the condition
• your opinion or preference

Treatment may include:

• antibiotics
• treatment of underlying cause
• bed rest (to relieve pain)
• aspirin
• corticosteroids

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