Symptoms
You may not have any symptoms of
lung cancer
, or you may have symptoms such as a cough
or shortness of breath that you might think are related to a respiratory
illness.
Symptoms of lung cancer may include:
- A new cough or a cough that does not go away. Smokers who have a
chronic cough from smoking may have a change in how severe their cough is or
how much they cough.
- Chest, shoulder, or back pain that does not go away and often
gets worse with deep breathing.
- New
wheezing
.
- Shortness of breath.
- Hoarseness.
- Coughing up blood or bloody mucus.
- Swelling in the neck and face.
- Difficulty swallowing.
- Weight loss and loss of appetite.
- Increasing fatigue and weakness.
- Recurring respiratory infections, such as
pneumonia
.
- Clubbing of the fingers and toes. The nails appear to bulge out
more than normal.
Lung cancer may spread (metastasize) to other parts of the
body. The most common sites are the bones, the brain, the liver, the other
lung, the lining of the heart (
pericardium
), the skin, and the
adrenal glands
. When lung cancer spreads, other
symptoms may also occur.
Symptoms of cancer that has spread to
the spine or bones may include:
- Bone pain.
- Weakness or numbness of the arms or legs.
- Back pain.
Symptoms of cancer that has spread to the brain may include:
- Seizures.
- Headaches.
- Change in alertness.
- Vision changes, such as double vision or new blind spots.
- Nausea or vomiting.
Symptoms of cancer that has spread to the liver or lymph nodes may include:
- Yellowing of the skin or eyes (jaundice).
- Lumps or bumps under the skin or enlarged
lymph nodes
.
- Decreased appetite.
- Weight loss.
American Cancer Society (2007). What are the key
statistics for lung cancer? Detailed Guide: Lung Cancer—Non–Small Cell. Available online:
http://www.cancer.org/docroot/CRI/content/CRI_2_4_1x_What_Are_the_Key_Statistics_About_Lung_Cancer_15.asp?sitearea=.
Ettinger DS (2008). Lung cancer and other pulmonary
neoplasms. In L Goldman, D Ausiello, eds., Cecil Medicine, 23rd ed., pp. 1456–1465. Philadelphia: Saunders Elsevier.
Crawford J (2007). Lung cancer. In DC Dale, DD
Federman, eds., ACP Medicine, section 12, chap. 8. New
York: WebMD.
Godtfredsen NS, et al. (2005). Effect of smoking
reduction on lung cancer risk. JAMA, 294(12):
1505–1510.
Theodore PR, Jablons D. (2006). Neoplasms of the lung
section of Thoracic wall, pleura, mediastinum, and lung. In GM Doherty, LW Way,
eds., Current Surgical Diagnosis and Treatment, 12th
ed., pp. 377–389. New York: McGraw-Hill.
Bain C, et al. (2004). Lung cancer rates in men and
women with comparable histories of smoking. Journal of the National Cancer Institute, 96(11): 826–834.
National Toxicology Program, U.S. Department of Health
and Human Services (2005). Report on Carcinogens, 11th
ed. Available online: http://ntp-server.niehs.nih.gov/ntp/roc/toc11.html.
Aldington S, et al. (2008). Cannabis use and risk of
lung cancer: A case-control study. European Respiratory Journal, 31(2): 280–286.
Annema JT, et al. (2005). Endoscopic ultrasound added to mediastinoscopy for preoperative staging of patients with lung cancer. JAMA, 294(8): 931–936.
Humphrey LL, et al. (2004). Lung cancer screening
with sputum cytologic examination, chest radiography, and computed tomography:
An update for the U.S. Preventive Services Task Force. Annals of Internal Medicine, 140(9): 740–753.
National Cancer Institute (2007). Lung Cancer PDQ: Screening—Health Professional Version. Available online:
http://www.cancer.gov/cancertopics/pdq/screening/lung/healthprofessional.
Winton T, et al. (2005). Vinorelbine plus cisplatin
vs. observation in resected non–small cell lung cancer. New England Journal of Medicine, 352(25): 2589–2597.
Fox JL, et al. (2004). The effect of smoking status on survival following radiation therapy for non–small cell lung cancer. Lung Cancer, 44(3): 287–293.
Dasgupta P, et al. (2006). Nicotine inhibits apoptosis induced by chemotherapeutic drugs by up-regulating XIAP and survivin. Proceedings of the National Academy of Sciences, 103(16): 6332–6337.
Simon CJ, Dupuy DE (2005). Current role of
image-guided ablative therapies in lung cancer. Expert Review of Anticancer Therapy, 5(4): 657–666.
International Adjuvant Lung Cancer Trial
Collaborative Group (2004). Cisplatin-based adjuvant chemotherapy in patients
with completely resected non–small-cell lung cancer. New England Journal of Medicine, 350(4): 351–360.
Spira A, Ettinger DS (2004). Multidisciplinary
management of lung cancer. New England Journal of Medicine, 350(4): 379–392.
Schabath MB, et al. (2005). Dietary phytoestrogens and
lung cancer. JAMA, 294(12): 1493–1504.
Goodman GE, et al. (2004). The beta-carotene and
retinol efficacy trial: Incidence of lung cancer and cardiovascular disease
mortality during 6-year follow-up after stopping beta-carotene and retinol
supplements. Journal of the National Cancer Institute,
96(23): 1743–1750.
U.S. Food and Drug Administration (2004). FDA
statement on Iressa. FDA Public Health Web Notification.
Available online:
http://www.fda.gov/bbs/topics/news/2004/new01145.html.
U.S. Food and Drug Administration (2006). FDA approves new combination therapy for lung cancer. FDA News. Available online: http://www.fda.gov/bbs/topics/NEWS/2006/NEW01488.html.
Chesnutt MS, et al. (2008). Pulmonary disorders. In SJ
McPhee et al., eds., Current Medical Diagnosis and Treatment, 47th ed., pp. 203–243. New York: McGraw-Hill.
National Cancer Institute (2007). Small Cell Lung Cancer PDQ: Treatment—Health Professional Version. Available online:
http://www.cancer.gov/cancertopics/pdq/treatment/small-cell-lung/healthprofessional.